Multiple factors can contribute to H. pylori eradication failure¹

Rising antibiotic resistance

Treatment complexity and
suboptimal patient adherence

Insufficient acid suppression

The importance of acid suppression should not be overlooked¹

Antibiotics like amoxicillin and clarithromycin are less effective in acidic environments
H. pylori bacteria are most vulnerable to eradication at neutral or near-neutral pH levels

Acid suppression is important because it improves the stability and effectiveness of antibiotics in H. pylori therapy¹

H. pylori=Helicobacter pylori;

PCAB=potassium-competitive acid blocker.