Multiple factors can contribute to
eradication failure
Rising antibiotic resistance
Treatment complexity and
suboptimal patient adherence
suboptimal patient adherence
Insufficient acid suppression
The importance of acid suppression should not be overlooked1
- Antibiotics like amoxicillin and clarithromycin are less effective in acidic environments
- H. pylori bacteria are most vulnerable to eradication at neutral or near-neutral pH levels
ACID SUPPRESSION HELPS MAINTAIN pH LEVELS THAT CAN ENHANCE ANTIBIOTIC EFFECTIVENESS2,3

H. pylori=Helicobacter pylori;
PCAB=potassium-competitive acid blocker.